Document 0079
 DOCN  M9490079
 TI    Th2-like CD8+ T cells showing B cell helper function and reduced
       cytolytic activity in human immunodeficiency virus type 1 infection.
 DT    9411
 AU    Maggi E; Giudizi MG; Biagiotti R; Annunziato F; Manetti R; Piccinni MP;
       Parronchi P; Sampognaro S; Giannarini L; Zuccati G; et al; Division of
       Clinical Immunology and Allergy, University of; Florence, Italy.
 SO    J Exp Med. 1994 Aug 1;180(2):489-95. Unique Identifier : AIDSLINE
       MED/94321903
 AB    We analyzed at clonal level the functional profile of circulating or
       skin-infiltrating T lymphocytes from two individuals infected with the
       human immunodeficiency virus type 1 (HIV-1), suffering from a Job's-like
       syndrome (eczematous dermatitis, recurrent skin and sinopulmonary
       infections, and hypergammaglobulinemia E) and showing virtually no
       circulating CD4+ T cells. Most of the CD3+ T cell clones generated from
       both patients were CD4- CD8+ TCR alpha beta +. The others were CD4- CD8-
       TCR alpha beta + which exhibited reduced mRNA expression for the CD8
       molecule or no mRNA expression for either CD4 or CD8 molecules. The
       great majority of both CD4- CD8+ and CD4- CD8- did not produce
       interferon (IFN) gamma and exhibited reduced cytolytic activity. Rather,
       most of them produced large amounts of both interleukin (IL) 4 and IL-5
       and provided B cell helper function for IgE synthesis. These data
       suggest that a switch of cytolytic CD8+ T cells showing a Th1-like
       cytokine secretion profile to cells that make Th2-type cytokines,
       exhibit reduced cytolytic potential, and provide B cell helper function
       can occur in the course of HIV-1 infection. These cells may contribute
       to the reduced defense against viral infections and intracellular
       parasites and account for the elevated IgE serum levels, eosinophilia,
       and the allergic-like clinical manifestations seen in a proportion of
       HIV-1-infected individuals.
 DE    Antigens, CD4/GENETICS/IMMUNOLOGY  Antigens, CD8/GENETICS/IMMUNOLOGY
       B-Lymphocytes/*IMMUNOLOGY  Clone Cells  Cytokines/BIOSYNTHESIS
       *Cytotoxicity, Immunologic  Human  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       Interleukin-4/IMMUNOLOGY  Job's Syndrome/COMPLICATIONS/IMMUNOLOGY
       Phenotype  Support, Non-U.S. Gov't  T-Lymphocytes,
       Helper-Inducer/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).